Conférence de chimie organique "N-heteroaromatics in inverse electron demand diels-alder cascades"
Pyrimidines are almost unreactive partners in Diels−Alder cycloadditions, and only reactions under drastic conditions have previously been reported. We will discuss how 2-hydrazonylpyrimidines can be exceptionally activated by trifluoroacetylation. This allows a Diels−Alder cycloaddition under very mild reaction conditions, leading to a large diversity of azaindazoles, a ubiquitous scaffold in medicinal chemistry.
Date : 12/09/2022 17:00 - 12/09/2022 18:00
Lieu : Salle académique 5ème étage Dpt Chimie
Orateur(s) : Professor Nicolas Blanchard
Organisateur(s) : Unité de Chimie Organique / UCO
Pyrimidines are almost unreactive partners in Diels−Alder cycloadditions with alkenes and alkynes, and only reactions under drastic conditions have previously been reported. We will discuss how 2-hydrazonylpyrimidines, easily obtained in two steps from commercially available 2-halopyrimidines, can be exceptionally activated by trifluoroacetylation. This allows a Diels−Alder cycloaddition under very mild reaction conditions, leading to a large diversity of azaindazoles, a ubiquitous scaffold in medicinal chemistry.
Contact :
Guillaume Berionni
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081724537
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guillaume.berionni@unamur.be
Plus d'info :
https://www.unamur.be/sciences/chimie/unitee-UCO
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