Boron-Relayed Strategies: From Building Blocks to C-C Bond Formation

This presentation will cover the following fields: Boron-promoted synthetic strategies New methods for accessing cyclobutenes and alkylidenecyclobutanes Four-membered heterocycles as new entries in drug discovery Catalyst-free cross-coupling reactions

Combining a facile preparation of organoboronates with their remarkable stability and functional group tolerance allows for the straightforward synthesis of four- and five-membered carbo- and hetero­cycles.

While most strategies rely on the ex situ preparation of boronic acids as isolated intermediates, we demonstrate that in situ transmetalation of sensitive organometallics with boron alkoxides can lead to great stabilization of such species at room temperature.

A considerable extension of the library of unsaturated strained structures is achieved through these sequences, expanding the potential applicability of such unusual building blocks.

Contact : Guillaume Berionni - 081724537 - guillaume.berionni@unamur.be
Plus d'info : http://www.cup.lmu.de/oc/didier/
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