Séminaire institut NISM "Réactions d'activation CH et de couplage par catalyse au palladium"
This lecture will present a new concept in the context of two cross-coupling reactions under homogeneous catalysis by palladium complexes
Date : 31/05/2018 17:00 - 31/05/2018 18:00
Lieu : Département Chimie / Salle CH22
Orateur(s) : Pr. Olivier Baudoin (Université de Bâle)
Organisateur(s) : Guillaume Berionni (Dpt Chimie)
NISM / UCO lecture on Thursday, May 31st at 5.00 pm
(Chemistry building, 2nd floor, room CH22)
Direct vs. migratory Pd-catalyzed cross-coupling
Prof. Olivier Baudoin
University of Basel, Switzerland
Our group's research is mainly focusing on the functionalization of unactivated C(sp3)-H bonds under catalysis by palladium(0) complexes. A first strategy, which we have been pursuing for the past 15 years, relies on intramolecular C-H activation and allows for the creation of a variety of interesting ring systems from simple precursors.
More recently, we have investigated a different strategy for the intermolecular functionalization of remote C(sp3)-H bonds via a Pd "chain-walk" mechanism. We showed that the site-selectivity of the cross-coupling on the alkyl chain can be controlled by the ligand, with bulky phosphines giving rise to the direct coupling product whereas homemade conformationally flexible ligands favor the migratory coupling product. This lecture will present this concept in the context of two cross-couplings: the arylation of ester enolates and the Negishi coupling.
Contact :
Guillaume Berionni
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081724537
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guillaume.berionni@unamur.be
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