Défense de thèse de doctorat en sciences chimiques "peptidic scaffolding"

Synthetic approaches toward functional peptidic scaffolding

Jury

Paolo TECILLA (Univ. Trieste), Solange LAVIELLE (Univ. P. et M. Curie, Paris), Mathieu SURIN (Univ. Mons), Daniel VERCAUTEREN, président (UNamur), Stéphane VINCENT (UNamur), Davide BONIFAZI, promoteur (UNamur)

Résumé

One of the recent and appealing avenues to confer a new functional essence to nanomaterials is represented by nano-biotechnology. Decorating judiciously nanomaterials with biomolecules enable to improve the biocompatibility, and the new functionality may lead to biohybrids with peculiar properties exploitable for targeted applications in biotechnology. During this Ph.D. I have been working on three projects that fall within this framework.

The first project addresses the design and formation of peptide nucleic acids (PNA)-adducts, amenable to self-assemble and form bi-dimensional porous networks upon deposition on surfaces. My work in this doctoral project was focused on the development and application of the 1,3-dipolar cycloaddition reaction strategy, selected to functionalise PNA.

The second project of my Ph.D. focuses on the synthesis and characterisation of amphiphilic b-sheets, designed to interface with bi-dimensional graphitic structures through a hydrophobic anchoring side appended with pyrenyl moieties; and which also displays a hydrophilic moiety targeted toward the medium, for possible further material processability.

The third doctoral project was developed in the frame of tissue engineering and it deals with the unidirectional organisation of yeast S. Pombe cells. More particularly, our strategy is based on a three-component assembly in which functional peptides, through the specific recognition by cellular membrane receptors, would be first anchored to cell surfaces, after which the cell self-assembly process would take place by host-guest interactions between a host appended to the peptide and a guest anchored to an oligonucleotide-based spacer. Preliminary results demonstrated the suitability of the fundamental design of our system.

La défense est publique

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