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Défense de thèse de doctorat en sciences chimiques "Clickable ADP-heptose"

Synthesis of Clickable ADP-heptose Analogues

Catégorie : défense de thèse
Date : 19/01/2015 15:00 - 19/01/2015 17:00
Lieu : Auditoire CH11, rue Grafé, 2, 5000 Namur
Orateur(s) : Tianlei LI
Organisateur(s) : Stéphane VINCENT

Olivier RIANT (UCL), Steven BALLET (VUB), Johan WOUTERS, président (UNamur), Steve LANNERS (UNamur), Stéphane VINCENT, promoteur (UNamur)


The main aim of this thesis is to synthesize a series of clickable ADP-β-heptose analogues to study the mechanism and the binding properties of WaaC. These compounds feature an ADP moiety, a mannose or a heptose subunit for mimicking the natural substrate of WaaC. All these characteristics are essential for the binding with the active site of WaaC. The protected azido-heptose and alkyne-heptose were synthesized from the protected L-heptose scaffolds which could be generated by a multi-step synthesis starting from α-methyl-D-mannoside. Two ADP-azido-mannose and one ADP-azido-heptose have been synthesized using the diallyl chlorophosphate as an effective phosphorylating reagent.

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